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Monoclonal Mouse anti Human CD8a

CD8a

accession:  P01732
   Size A       $
   Size B      500ug  $400
   Size C      1mg  $ 600
Clone  :  RKCD8
Isotype  :  IgG2a
Catalog no. :  RMA01732
Applications:
  • Western blot: This monoclonal antibody has been tested in WB analysis of human CD8 . A suitable range of concentrations of this antibody for WB detection is 0.5-2 µg/ml.
 
Source:
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with Human fetal thymocytes.
 
Species reactivity:
Human
 
Purification:

The IgG fraction of the tissue culture supernatant was purified by Protein A affinity chromatography.

 
Presentation:
Lyophilized from sterile filtered PBS solution at a concentration of 1mg/ml .
 
Reconstitution:
A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers
 
Storage:
The lyophilized antibody is stable for at least 1 year  from date of receipt at -20° C.
Upon reconstitution, this antibody can be stored in working aliquots at 2° - 8° C , or at -20° C for six months without detectable loss of activity.

Avoid repeated freeze/thaw cycles.

 
Usage:

This antibody product is for research purposes only.It may not be used for therapeutics or diagnostic purposes.

 

CD8

The cell surface glycoprotein CD8 plays an important role in the development and function of MHC3 class I-restricted T cells. CD8 fulfils its function through interacting via its extracellular domain with MHC class I proteins and via its intracellular domain with the tyrosine kinase Lck (1, 2). An interaction of both the T cell receptor (TCR) and CD8 with MHC proteins enhances the adhesion between the T cell and the antigen- presenting cell.The coreceptor CD8 is expressed as a CD8ab heterodimer on major histocompatibility complex class I-restricted TCRab T cells, and as a CD8aa homodimer on subsets of memory T cells, intraepithelial lymphocytes, natural killer cells, and dendritic cells.

Related Publications:
effective simian immunodeficiency virus-specific CD8+ t cells lack an easily detectable, shared characteristic
J. Virol., Jan 2010; 84: 753 - 764.
tumor immunity against a simian virus 40 oncoprotein requires CD8+ t lymphocytes in the effector immune phase
J. Virol., Jan 2010; 84: 883 - 893.
CD8+ t cell control of hepatitis b virus replication: direct comparison between cytolytic and noncytolytic functions
J. Immunol., Jan 2010; 184: 287 - 295.
altered CD8+ t cell immunodominance after vaccinia virus infection and the naive repertoire in inbred and f1 mice
J. Immunol., Jan 2010; 184: 45 - 55.
specific CD8 t cells in ige-mediated allergy correlate with allergen dose and allergic phenotype
Am. J. Respir. Crit. Care Med., Jan 2010; 181: 7 - 16.




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Antibodies:
Purified Polyclonal
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product_icon_17.jpg Monoclonal Mouse anti Human CD8a
 
 
 
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