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Monoclonal Mouse anti Human CD5

CD5

accession:  P06127
   Size A       $
   Size B      500ug  $400
   Size C      1mg  $ 600
Clone  :  RKCD5
Isotype  :  IgG1
Catalog no. :  RMA06127

 

 

Applications:
  • Western blot: This monoclonal antibody has been tested in WB analysis of human CD5 . A suitable range of concentrations of this antibody for WB detection is 0.5-2 µg/ml.
 
Source:
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with human peripheral blood lymphocytes.
 
Species reactivity:
Human
 
Purification:

The IgG fraction of the tissue culture supernatant was purified by Protein A affinity chromatography.

 
Presentation:
Lyophilized from sterile filtered PBS solution at a concentration of 1mg/ml .
 
Reconstitution:
A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers
 
Storage:
The lyophilized antibody is stable for at least 1 year  from date of receipt at -20° C.
Upon reconstitution, this antibody can be stored in working aliquots at 2° - 8° C, or at -20° C for six months without detectable loss of activity. 

Avoid repeated freeze/thaw cycles.

 
Usage:

This antibody product is for research purposes only.It may not be used for therapeutics or diagnostic purposes. 

CD5

CD5 is a 67-kDa membrane glycoprotein belonging to the ancient and conserved family of receptors containing extracellular domains of the scavenger receptor cysteine-rich type. CD5 is a lymphoid-specific molecule expressed on thymocytes, mature T cells, and a subset of normal B cells, known as B-1a cells. CD5 also exists as a circulating protein in serum, resulting from proteolytic cleavage following lymphocyte activation.The CD5 cytoplasmic tail is devoid of intrinsic enzymatic activity, but it is well adapted for signal transduction. It has been shown that the CD5 signaling pathway involves several signal-transducing molecules.Surface expression of CD5 is tightly regulated during T cell development in the thymus. Low levels of CD5 are detected on immature CD4CD8 (double-negative) thymocytes, independently of TCR rearrangement. A further increase in CD5 expression on double-negative thymocytes is seen after engagement of the pre- TCR.Higher surface CD5 levels are achieved later at both double-positive (CD4+CD8+) and single- positive (CD4+CD8 or CD4- CD8+) stages.

Related Publications:
correlation of autoantibodies and CD5+ b cells in ocular adnexal marginal zone b cell lymphomas
J. Clin. Pathol., Jan 2010; 63: 79 - 82.
CD5 expression identifies a subset of splenic marginal zone lymphomas with higher lymphocytosis: a clinico-pathologic, cytogenetic and molecular study of 24 cases
Haematologica, Dec 2009; 10.3324/haematol.2009.011049.
phase ii study of lenalidomide in combination with rituximab for patients with CD5+/cd20+ hematologic malignancies who relapse or progress after rituximab. interim analysis.
Blood (ASH Annual Meeting Abstracts), Nov 2009; 114: 2376.
brisk lymphocytosis with aberrant expression of CD5 in the leukemic phase of follicular lymphoma.
Blood (ASH Annual Meeting Abstracts), Nov 2009; 114: 5033.
viral antigens trigger granzyme b secretion by human CD5+ b1 cells in the presence of interleukin 21.
Blood (ASH Annual Meeting Abstracts), Nov 2009; 114: 4729.




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