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Mouse Exodus-2 Recombinant

Exodus-2

accession:  P84444
   Size A     5ug   $ 70
   Size B      20ug  $160
   Size C      1mg  $ 2700
Domain  :  IL8
Gene  :  CCL21
Catalog no. :  RKP84444

Source:
Optimized DNA sequence encoding Mouse Exodus-2 mature chain was expressed in Escherichia Coli.

 
Molecular weight:

Native mouse Exodus-2 is generated by the proteolytic removal of the signal peptide
and propeptide, this molecule has a calculated molecular mass of approximately 12 kDa.

Recombinant mouse Exodus-2 is a disulfide-linked homodimeric protein consisting of 111 amino acid residue subunits, and migrates as an approximately 12 kDa protein under non-reducing and reducing conditions in SDS-PAGE.


 
Purity:
>95%, as determined by SDS-PAGE and HPLC

 
Biological Activity:
Determined by its ability to chemoattract total lymphocyte population using a concentration range of 10.0-100.0 ng/ml.

 
Protein Sequence:
        10         20         30         40         50         60 
MAQMMTLSLL SLVLALCIPW TQGSDGGGQD CCLKYSQKKI PYSIVRGYRK QEPSLGCPIP 

        70         80         90        100        110        120 
AILFSPRKHS KPELCANPEE GWVQNLMRRL DQPPAPGKQS PGCRKNRGTS KSGKKGKGSK 

       130 
GCKRTEQTQP SRG 
(*)Complete precursor sequence shown, expressed chain highlighted
 
Endotoxin:
Endotoxin content was assayed using a LAL gel clot method.
Endotoxin level was found to be less than 0.1 ng/µg(1EU/µg).

 
Presentation:
Recombinant mouse Exodus-2 was lyophilized from a 0.2 μm filtered PBS solution.

 
Reconstitution:
A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers.

 
Storage:
The lyophilized protein is stable for at least 2 years from date of receipt at -20° C.
Upon reconstitution, this cytokine can be stored in working aliquots at 2° - 8° C for one month, or at -20° C for six months, with a carrier protein without detectable loss of activity.

Avoid repeated freeze/thaw cycles.

 
Usage:
This cytokine product is for research purposes only.It may not be used for therapeutics or diagnostic purposes.

 

Exodus-2

Exodus-2, which is a member of the family of CC- Chemokines, has a unique 36 (murine) or 37 (human) amino acid carboxyl-terminal extension not seen in other chemokines. Exodus-2 selectively stimulates the chemotaxis of adult T-lymphocytes and is expressed preferentially in lymph node tissue. Exodus-2 is critical for adult T-cell adhesion to high endothelial venules in lymph nodes, a rate-limiting step for T- cell trafficking through nodal tissue.

Related Publications:
the cc chemokine thymus-derived chemotactic agent 4 (tca-4, secondary lymphoid tissue chemokine, 6ckine, Exodus-2) triggers lymphocyte function–associated antigen 1–mediated arrest of rolling t lymphocytes in peripheral lymph node high endothelial venules
J. Exp. Med., Jan 2000; 191: 61.




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Related Products:
product_icon_8.jpg Human Exodus-2 Recombinant
product_icon_8.jpg Mouse Exodus-2 Recombinant
 
 
 
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