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Human Endocrine Gland Vascular Endothelial Growth Factor Rec

EG-VEGF

accession:  P58294
   Size A     5ug   $ 70
   Size B      20ug  $160
   Size C      1mg  $ 2700
Domain  :  4 helix cytokine core
Gene  :  PROK1
Catalog no. :  RKP58294
Source:
Optimized DNA sequence encoding Human EG-VEGF mature chain was expressed in Escherichia Coli.

 
Molecular weight:

Native human EG-VEGF is generated by the proteolytic removal of the signal peptide, This molecule has a calculated molecular mass of approximately 10 kDa.
 

Recombinant EG-VEGF is a disulfide-linked monomer protein consisting of 87 amino acid residue subunits, and migrates as an approximately 10 kDa protein under non-reducing and reducing conditions in SDS-PAGE.


 
Purity:
>98%, as determined by SDS-PAGE and HPLC

 
Protein Sequence:
        10         20         30         40         50         60 
MRGATRVSIM LLLVTVSDCA VITGACERDV QCGAGTCCAI SLWLRGLRMC TPLGREGEEC 

        70         80         90        100 
HPGSHKVPFF RKRKHHTCPC LPNLLCSRFP DGRYRCSMDL KNINF 
(*)Complete precursor sequence shown, expressed chain highlighted
 
Endotoxin:
Endotoxin content was assayed using a LAL gel clot method.
Endotoxin level was found to be less than 0.1 ng/µg(1EU/µg).

 
Presentation:
Recombinant EG-VEGF was lyophilized from a 0.2 μm filtered PBS solution.

 
Reconstitution:
A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers.

 
Storage:
The lyophilized protein is stable for at least 2 years from date of receipt at -20° C.
Upon reconstitution, this cytokine can be stored in working aliquots at 2° - 8° C for one month, or at -20° C for six months, with a carrier protein without detectable loss of activity.

Avoid repeated freeze/thaw cycles.

 
Usage:
This cytokine product is for research purposes only.It may not be used for therapeutics or diagnostic purposes.

 

EG-VEGF

This factor is identical with prokineticin-1 and is a member of the AVIT protein family. Expression of human EG-VEGF messenger RNA is restricted to the steroidogenic glands, ovary, testis, adrenal and placenta and is often complementary to the expression of VEGF. EG-VEGF has been identified as a mitogen specific for the endothelium of steroidogenic glands. EG- VEGF resembles VEGF in that it causes extensive angiogenesis and cyst formation when delivered in the ovary. EG-VEGF differs from VEGF in that it does not promote angiogenesis in the cornea or skeletal muscle. Two receptors have been characterized, these receptors are expressed in gastrointestinal organs, endocrine glands and other tissues. The G-protein- coupled receptor ZAQ and the G-protein-coupled receptor I5E function as the EG-VEGF receptor.

Related Publications:
the endocrine-gland-derived vascular endothelial growth factor (EG-VEGF)/prokineticin 1 and 2 and receptor expression in human prostate: up-regulation of EG-VEGF/prokineticin 1 with malignancy
Endocrinology, Sep 2006; 147: 4245 - 4251.
pk1/EG-VEGF induces monocyte differentiation and activation
J. Leukoc. Biol., Aug 2005; 78: 426 - 434.




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product_icon_8.jpg Human Endocrine Gland Vascular Endothelial Growth Factor Recombinant
 
 
 
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