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Monoclonal Mouse anti human Interleukin-2

IL-2

accession:  P60568
   Size A       $
   Size B      500ug  $400
   Size C      1mg  $ 600
Clone  :  four helix cytokine core
Isotype  :  IgG1
Catalog no. :  RMA04351
Applications:
  • Western blot: This monoclonal antibody has been tested in WB analysis of human IL-2 . A suitable range of concentrations of this antibody for WB detection is 0.5-2 µg/ml.
 
Source:
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with recombinant E. coli-derived Human IL-2. 
 
Species reactivity:
Human,Mouse,Rat
 
Purification:

The IgG fraction of the tissue culture supernatant was purified by Protein G affinity chromatography.

 
Presentation:
Lyophilized from sterile filtered solution at a concentration of 1mg/ml in citrate-phosphate buffer pH7.0, with 0.02%Proclin 300 as a preservative.
 
Endotoxin:
Endotoxin content was assayed using a LAL gel clot method.
Endotoxin level was found to be less than 0.1 ng/µg(1EU/µg).
 
Reconstitution:
A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers
 
Storage:
The lyophilized antibody is stable for at least 1 year  from date of receipt at -20° C.
Upon reconstitution, this antibody can be stored in working aliquots at 2° - 8° C for one month, or at -20° C for six months without detectable loss of activity.

Avoid repeated freeze/thaw cycles.

 
Usage:

This antibody product is for research purposes only.It may not be used for therapeutics or diagnostic purposes.

 

IL-2

IL2 is produced mainly by T- cells expressing the surface antigen CD4 following cell activation by mitogens or allogen. Interleukin-2 (IL-2) has multiple, sometimes opposing, functions during an inflammatory response. It is a potent inducer of T- cell proliferation and T- helper 1 (Th1) and Th2 effector T-cell differentiation and provides T cells with a long-lasting competitive advantage resulting in the optimal survival and function of memory cells. In a regulatory role, IL-2 is important for the development, survival, and function of regulatory T cells, it enhances Fas- mediated activation-induced cell death, and it inhibits the development of inflammatory Th17 cells. Thus, in its dual and contrasting functions, IL-2 contributes to both the induction and the termination of inflammatory immune responses.

Related Publications:
vaccination with live leishmania major and cpg dna promotes IL-2 production by dermal dendritic cells and nk cell activation
Clin. Vaccine Immunol., Sep 2009; 10.1128/CVI.00249-09.
erk and not p38 pathway is required for il-12 restoration of t cell IL-2 and ifn- in a rodent model of alcohol intoxication and burn injury
J. Immunol., Sep 2009; 183: 3955 - 3962.
a glucocorticoid amplifies IL-2-induced selective expansion of cd4+cd25+foxp3+ regulatory t cells in vivo and suppresses graft-versus-host disease after allogeneic lymphocyte transplantation
Acta Biochim Biophys Sin, Sep 2009; 41: 781 - 791.
self-peptides prolong survival in murine autoimmunity via reduced IL-2/il-7-mediated stat5 signaling, cd8 coreceptor, and v2 down-regulation
J. Immunol., Sep 2009; 183: 3130 - 3138.
single nucleotide polymorphisms in genes for IL-2, il-6 and tnf- influence on osteolysis and survival of total hip arthroplasty
J Bone Joint Surg Br Proceedings, Sep 2009; 91-B: 473.




by class:
Cytokines
Chemokines
Growth factors
CD markers
Viral Antigens
Other
by species:
Human
mouse
Rat
Antibodies:
Purified Polyclonal
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