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Monoclonal Mouse Anti Human Interleukin-6


accession:  RAP05231
   Size A       $
   Size B      500ug  $400
   Size C      1mg  $ 600
Clone  :  SB9H6
Isotype  :  IgG1
Catalog no. :  RMA05231
  • Direct ELISA: This antibody can be used at 0.5-1μg/mLwith the appropriate secondary reagents to detect human Interleukin-6. The detection limit for human IL-6 is approximately 2ng/well.
  • Western blot: This monoclonal antibody has been tested in WB analysis of human IL-6 . A suitable range of concentrations of this antibody for WB detection is 0.5-2 µg/ml.
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with recombinant E. coli-derived Human IL-6. 
Species reactivity:
Human IL-6

The IgG fraction of the tissue culture supernatant was purified by Protein A affinity chromatography.

Prepared from sterile filtered solution at a concentration of 1mg/ml in PBS with 5% trehalose.
This antibody can be stored in working aliquots at 2° - 8° C for one month, or at -20° C for six months without detectable loss of activity.

Avoid repeated freeze/thaw cycles.


This antibody product is for research purposes only.It may not be used for therapeutics or diagnostic purposes. 



IL6 is produced by many different cell types. The main sources in vivo are stimulated monocytes, fibroblasts, and endothelial cells. Macrophages, T-cells and B-lymphocytes, granulocytes, smooth muscle cells, eosinophils, chondrocytes, osteoblasts, mast cells, glial cells, and keratinocytes also produce IL6 after stimulation. IL6 is a member of a family of cytokines, which also includes LIF, CNTF, Oncostatin M, IL11, and CT- 1. All known members of the IL6 cytokine family induce hepatic expression of acute phase proteins. The IL6 receptor is expressed on T-cells, mitogen-activated B-cells, peripheral monocytes and some macrophage- and B-cell derived tumor cell types. It is not expressed in resting B-cells but in resting T- cells. The IL6 receptor is a strongly glycosylated protein of 80 kDa and a length of 449 amino acids. It has been designated CD126.

Related Publications:
IL-6 protects against hyperoxia-induced mitochondrial damage via bcl-2–induced bak interactions with mitofusions
Am. J. Respir. Cell Mol. Biol., Oct 2009; 41: 385 - 396.
long-term safety and efficacy of tocilizumab, an anti-IL-6 receptor monoclonal antibody, in monotherapy, in patients with rheumatoid arthritis (the stream study): evidence of safety and efficacy in a 5-year extension study
Ann Rheum Dis, Oct 2009; 68: 1580 - 1584.
the second bovine β-galactoside-2,6-sialyltransferase (st6gal ii): genomic organization and stimulation of its in vitro expression by IL-6 in bovine mammary epithelial cells
Glycobiology, Oct 2009; 19: 1082 - 1093.
IL-6 -174g/c promoter polymorphism in acute appendicitis
Lab Med, Oct 2009; 40: 600 - 603.
cell surface-bound il-1 is an upstream regulator of the senescence-associated IL-6/il-8 cytokine network
PNAS, Sep 2009; 10.1073/pnas.0905299106.

by class:
Growth factors
CD markers
Viral Antigens
by species:
Purified Polyclonal
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