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Human Follicle Stimulating Hormone

FSH

accession:  P01225
   Size A     2ug   $ 70
   Size B      10ug  $160
   Size C      1mg  $ 4700
Domain  :  cystine knot growth factor
Gene  : 
Catalog no. :  RKP01225

Source:
Optimized DNA sequence encoding Human FSH mature chain was expressed in CHO.

 
Molecular weight:
Follicle stimulating hormoneis a glycoprotein with molecular mass of 30kDa.
FSH is a heterodimeric hormone consisting of 92 amino acids alpha chain and 111 amino acids beta chain.

 
Purity:
>95%, as determined by SDS-PAGE and HPLC

 
Biological Activity:
Activity was determined  to be 1x104 IU/mg protein

 
Endotoxin:
Endotoxin content was assayed using a LAL gel clot method.
Endotoxin level was found to be less than 0.1 ng/µg(1EU/µg).

 
Presentation:
FSH was lyophilized from a 0.2 μm filtered solution.

 
Reconstitution:
A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers.

 
Storage:
The lyophilized protein is stable for at least 2 years from date of receipt at -20° C.
Upon reconstitution, this product can be stored in working aliquots at 2° - 8° C for one month, or at -20° C for six months, with a carrier protein without detectable loss of activity.

Avoid repeated freeze/thaw cycles.

 
Usage:
This product is for research purposes only.It may not be used for therapeutics or diagnostic purposes.

              

 

FSH

Follicle stimulating hormone (FSH) is a hormone synthesised and secreted by gonadotropes in the anterior pituitary gland. FSH and LH act synergistically in reproduction: In women, in the ovary FSH stimulates the growth of immature Graafian follicles to maturation. As the follicle grows it releases inhibin, which shuts off the FSH production. In men, FSH enhances the production of androgen- binding proteinby the Sertoli cells of the testes and is critical for spermatogenesis. In both males and females, FSH stimulates the maturation of germ cells. In females, FSH initiates follicular growth, specifically affecting granulosa cells. With the concomitant rise in inhibin B FSH levels then decline in the late follicular phase. This seems to be critical in selecting only the most advanced follicle to proceed to ovulation. At the end of the luteal phase, there is a slight rise in FSH that seems to be of importance to start the next ovulatory cycle. Like its partner, LH, FSH release at the pituitary gland is controlled by pulses of gonadotropin- releasing hormone(GnRH). Those pulses, in turn, are subject to the estrogen feed-back from the gonads.

Related Publications:
the β104–109 sequence is essential for the secretion of correctly folded single-chain β horse lh/cg and for its FSH activity
J. Endocrinol., Oct 2009; 203: 167 - 174.
androgen, progesterone, and FSH receptor polymorphisms in ovarian cancer risk and outcome
Endocr. Relat. Cancer, Sep 2009; 16: 1005 - 1016.
effects of highly purified urinary FSH and human menopausal FSH on uterine myoelectrical dynamics
Mol. Hum. Reprod., Aug 2009; 10.1093/molehr/gap076.
a double-blind, non-inferiority rct comparing corifollitropin alfa and recombinant FSH during the first seven days of ovarian stimulation using a gnrh antagonist protocol
Hum. Reprod., Aug 2009; 10.1093/humrep/dep291.
does the estradiol level on the day of human chorionic gonadotrophin administration have an impact on pregnancy rates in patients treated with rec-FSH/gnrh antagonist?
Hum. Reprod., Aug 2009; 10.1093/humrep/dep290.




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product_icon_8.jpg Human Follicle Stimulating Hormone
 
 
 
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